/sci/ - Science & Math

Can we settle this once and for all? Which is the best between aripiprazole and bexpiprazol

>>14607312
how much are you being paid by the producers of those drugs in order to get you to advertise their products here?

How do I undo a lifetime of sitting hunched over a computer? Posture wise I mean
And how many times per day do you get asked to look at someones fungus?

I have high BP and some mild anxiety. Was on Propranolol for a while and stopped after I quit drinking thinking that getting sober solved my high BP.
Recently I thought I was having a heart attack, out of nowhere: chest pain, tachycardia, high BP, lightheaded, nausea, the works. Went to ER who determined I was having a panic attack. My PCP is booked months out so his NP got me started on metoprolol.

My question is: would it be unreasonable to ask him for a handful of valium/ativan/whatever when I see him next? I don't want to come off as a drug seeker and I've only had ~3 legitimate panic attacks over the last 10 years including this one. I see no need for a ton of benzos but I would like to have something on hand to avoid the unpleasantness of another 4hr ER visit if this happens again.
INB4: Lethal dose of morphine

>>14607704
Go see a doctor shopper. he might even be honest with you and say something like ‘how much Oxycotin do you want so you can leave me alone’

why do doctors' handwriting suck so god damn much

is coffee good for you?

>>14607738
Fuck yeah!

>>14607704
Have you tried something simple like theanine?

>>14607312
Aripiprazole clearly

>>14607704
No benzos for you. Get owned junkie

>>14603376
Did that fix the problem for her?
Anyone else got anything?

How is psychiatry even real? Like they can forcefully detain people cause of a hack without any evidence besides cause I think so saying they're dangerous. How is this accepted by the medical establishment especially after the ton of other dumb shit these conmen have done like lobotomy and labeling homosexuality as a mental illness.

>>14608121
Without any evidence besides cause they think so*

>>14608121
>>14608182
Because it's made up, as political weapon and very profitable money scheme for drug creation.
There is no mention of mental illness before ~1920. It's also the biggest legal criminal organization of human abuse and killing.
The only realing thing of these drugs is that they make you a junkie. It can only change your feelings, but not rewire or "undamage" parts of your brain. The chemistry of these pills is laughable.

Nothing changed since drilling skulls for lobotomy 50-70 years ago, it's the same people and the same wisdom

>>14608121
>>14608182
>>14608198
Lol, lmao
Psychiatry does important work by keeping schizos off the streets. Unvoluntary admission is kept in check by needing multiple doctors and a judge (in my country at least) to approve. Typically this happens if a patient is a danger to themselves or others due to psychiatric illness. So take your meds and stop shitting up our threads

Objectively speaking, how fucked is Ronnie Coleman's spine? What would your day to day look like dealing with picrelated?

>>14608287
>more

>>14607704
How much do you weight?

>>14606244
I got the same course but the material is too hard to sit through watching, did you watch all of it? I'm thinking about using anki decks from reddit and just using the tests but I hear they're not super representative. I have a problem with procrastinating so I'm mildly fucked with about a month to go.
Why'd you take the aamc tests a month before taking the exam? Isn't the usual recommendation to take them in the weeks leading up to the exam?

Responded in the old thread

>>14608253
>schizos
But there is actually no way to prove someone is a schizo, like you can with say lung cancer.
>multiple doctors
Multiple hacks sure, during trials lawyers can bring all sort of experts for either side.

I drink too much energy drinks. How bad are they actually are?

>>14608369
frontal lobe atrophy for example.

>>14607091

>>14607091

>>14608629
they have a high glycemic index, that's like a punch to your pancreas

>>14608851
Coorelation doesn't mean causcation, frontal lobe antrophy can mean you're living like vegetable with no social iteractions or any work and hobby, which frontal lobe is responsible for, and like any unused organ, it slowly degenerates. And that can be common with schizos, it's silly to call it reason though. You sound like they're infected with some virus that causes mayhem in their brain destroying brain cells left and right, fake science.

>>14608993
>punch to your pancreas
whats the worst that could happen? removal of pancreas?

>>14608253
From your initial smartass laughs i expected something more than laying off the reasoning to some authority, you don't actually understand half of the shit that goes out of your mouth

What is the easiest medical job? I am talking least responsibility and physical strain.

Reading all the covid stuff on here is giving me massive anxiety because I just tested positive (fully vaxxed)
Are all the people just schizos or am I actually fucked?

>>14609181
Chances are nothing is going to happen. I got vaxxed twice (no booster) and caught the coof too, lived through it. The schizo's are just doomposting and scaremongering like retards because that's all they can do.

>>14609209
I'm going to go with that
I've been getting lightheaded and dizzy but I'm pretty sure that is more the anxiety than the covid
This website ruined my mind

>>14607091
what happened to the clampedanon?

>>14608287
>>14608295
You get used to it and don't feel a thing if you're not old and frail.

>>14609074
Get owned, I’m only gonna release you from the clinic after I’ve put you on 2 depot injections

What does /med/ think of intranasal breast milk therapy?
There's studies of intranasal breast milk in infants significantly reducing brain injury
https://pubmed.ncbi.nlm.nih.gov/30386923/
https://scienceblog.com/529931/treatment-uses-breast-milk-up-the-nose-of-preemies-to-save-life/

you can take human breast milk even and put it into dfo and use that intranasally
Deferoxamine increases the proliferation of neurons from neural progenitor cells and increases stem cell proliferation and pluripotency
using dfo intranasally during a stem cell transplant would force all of those to be trafficked to the brain tissues in a more accurate fashion

>>14609932
>What does /med/ think of intranasal breast milk therapy?
Neat if it helps premature infants, probably irrelevant for everyone/everything else if you were implying something else? Otherwise you're just talking about neural regenerative stem cell therapy, something that has been sought after and studied for quite some time now, and you wouldn't need human breast milk for that.

e.g. https://pubmed.ncbi.nlm.nih.gov/33671500/

>>14609943

You fucking mong

Human breastmilk is much easier to make than stem cells
If they can be used to help infants recover from TBIs that's rad af

>>14609932

You're retarded
These babies are getting their own mother's milk within 2 hrs of it being made

You're talking about fucking mammalian stem cells this isn't just some saccharomyces bullshit you can keep on ice in the post

Just steal a bitch and milk her and then snort that shit and you'll be a God I guarantee it faggot

>>14607091
>DO NOT offer advice (just fucking go see your doctor)
>"don't give advice"
>*gives advice*

>>14607342
How much do OPs of these threads get paid to advertise for the medical industrial complex?
>b-but mine is funded by taxes instead of insurance companies
Changes literally nothing.

Using intranasal deferoxamine and insulin greatly improve function of our braincells through mitigation of oxidative stress and insulin resistance. That includes the sensory processing done by 5ht3, pv, and somatostatin interneurons and these control the visual encoding of our eyesight.
Defects in somatostatin interneuron populations in relation to pv interneurons contribute to autism, parkinsons, alzheimers and schizophrenia induced cognitive dysfunction. The same is true for your auditory processing, recall memory, memory formation, smell function, taste are all encoded by the activity of our gaba interneurons on pyramidal cells.
Defects in these interneuron populations is called hypofrontality. The relationship these interneurons have with pyramidal cells is called synchronicity. By improving neurogenesis and reducing oxidative stress induced by iron we promote greater expression of these interneurons and improves their reactivity.
I've removed a large degree of iron from my brain that reduces the functional activity of my braincells. Neuroinflammation is induced by a variety of factors including lps induced activity on microglial cells that release tnf-a, and il-6 which activates astrocytes to release hepcidin that accumulates in your brain cells
This defect observed in our brain cells encourages cellular senescence, synaptic defects, reactive oxygen species formation and they become susceptible to glutamatergic disinhibition that promotes excitotoxicity
Insulin protects against excitotoxicity and cellular dysfunction by serving many roles in promoting glucose metabolism and protein synthesis. A loss in somatostatin interneurons in the hypothalamus due to insulin resistance recapitulates late stage diabetic phenotypes.
Most of the time I feel like I'm just at perfection cognitively. There's a point that we can go even further beyond
No human has ever done this before and we, /med, are giving an example to humanity.
Life doesn't have to be so hard anymore

Really surreal stuff
Deferoxamine induces stemcell renewal as well
the survival of our neural stem cell niches are reliant on igf2, insulin, and MGF signalling
and you can take human placenta extract and likely use that intranasally
https://pubmed.ncbi.nlm.nih.gov/18560414/
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3456
https://pubmed.ncbi.nlm.nih.gov/9477167/
>HPE contains hepatocyte growth factor (HGF), but the mitogenic effect of HPE cannot be explained by the effect exerted by HGF alone, since both the labeling index in vivo and hepatocellular DNA synthesis in vitro stimulated by HPE were much higher than those stimulated by HGF alone when the applied doses of HGF were set to be almost the same level between each case.
human placenta extract has many stem cell proliferating effects.
https://pubmed.ncbi.nlm.nih.gov/21354355/
human placenta extract is probably cheaper than autologous stem cell transplantation and can be mixed with DFO
the dfo would deprive viruses and bacteria of iron so it'd further improve the therapeutic index and DFO suppresses prion disease so dont have to worry about that
https://onlinelibrary.wiley.com/doi/10.1002/tkm2.1075
Human placenta extract ameliorates memory dysfunction and dendritic atrophy in a 5XFAD mouse model of Alzheimer's disease
Laennec is fairly expensive stuff but this model uses IP injections. Intranasal use should be significantly stronger
You can buy it anywhere on the internet

https://journals.asm.org/doi/full/10.1128/AAC.45.12.3560-3565.2001
We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against
a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by
deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing
irreversible damage, thus indicating a different mode of action. Penetration was demonstrated by
showing DFO uptake by high-pressure liquid chromatography analysis. By using calcein-AM as an
indicator, exposure to DFO was shown to cause a reduction inP. carinii cytoplasmic free iron. Exposure
to ≥100 μM DFO for ≥8 h in vitro caused growth to cease and cell numbers to decline over several
days. This direct and irreversible damage to P. carinii led to the prediction that infrequent delivery of
DFO to the lungs via an aerosol would be an effective treatment in the animal model of PCP. This
prediction was confirmed by demonstrating that a once-a-week aerosol treatment of rats was 100%
effective both as a prophylactic and as a curative treatment in a rat model of PCP.
https://pubmed.ncbi.nlm.nih.gov/1708429/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801370/
https://pubmed.ncbi.nlm.nih.gov/7532647/
https://pubmed.ncbi.nlm.nih.gov/7511676/
We can completely reverse covid induced lung injury with nebulized deferoxamine
it will cure nearly all lung disorders and revert our lung function to a more youthful state
nebulized DFO is even more novel for the treatment of disorders of aging than intranasal DFO

Aerosolized Deferoxamine completely reverses smoke induced lung injury and has the potential to
reverse the progression of all chronic lung conditions including cystic fibrosis, lung cancer, Covid,
COPD, asthma and restore our lung function to a youthful state while protecting us from the stressors

>>14610678
of air pollution. 10-17% DFO solutions are whats used in these mouse studies and it's easily
replicatable with a nebulizer.
Anyone interested in using this to treat their CFS alongside intranasal DFO give a report here.
Cystic fibrosis is a condition of iron accumulation in the lung tissue.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419499/
Blood and sputum samples were collected from 12 subjects with moderate‐to‐severe CF (median
percentage‐predicted forced expiratory volume in 1 second (FEV1%) = 29%; median weight = 56 kg)
within 24 hours of starting and completing a course of systemic antibiotics.
Results: After treatment, subjects showed median FEV1% and body weight improvements of 4.5% and
2.0 kg, respectively (p < 0.05). Median serum iron rose by 2.4 μmol/L (p < 0.05), but 75% of patients
remained hypoferremic. Median serum IL‐6 and hepcidin‐25 levels fell by 12.1 pg/mL and 37.5 ng/mL,
respectively (p < 0.05). Median serum erythropoietin (EPO) and hemoglobin levels were unaffected by
treatment. We observed a trend toward lower sputum iron content after treatment.
PubMed Central (PMC)
Clinical studies support the premise that iron homeostasis is uniquely aberrant in this disease. The iron
content of CF sputum is approximately 2.5–5.5 times higher than sputum from patients with chronic
obstructive pulmonary disease (COPD) and about 3.4–4.2 times higher than sputum from normal
controls. 8 , 9 , 10 Reid et al. 11 reported a significant direct relationship between sputum iron and
quantitative culture of PA, suggesting that its growth is related to iron availability. Three investigations
9 , 10 , 11 with a total of 34 subjects have revealed that sputum iron content does not change after
CFPE therapy, but none of them addressed iron‐related hematologic parameters.

>>14610678
>>14610682
This is how lung fibrosis occurs is from hepatic hepcidin release which promotes defects in proteostasis
within the lungs leading to iron accumulation in lung tissue
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694836/
^ Read this entire paper and come back to me anons
It's not hyperbole if its the actual mechanistic data describing lung fibrosis and iron homeostasis in the
lungs
Lung fibrosis enters the iron age-Free Access
https://pubmed.ncbi.nlm.nih.gov/31960628/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561208/
Intranasal deferoxamine provides 200 fold higher brain concentrations than IV use and doesnt require
lengthy iv injection procedures. https://pubmed.ncbi.nlm.nih.gov/19509317/

It's demonstrated that opioids induce endolysosomal deacidification in our neurons which promotes iron accumulation in the cytosol. This provokes a functional iron deficiency in the mitochondria and upregulation of ferritin heavy chain within the cytosol and this locks of iron that can't serve proteostatic functions. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675873/ free iron that's accumulated through a variety of neuroinflammatory insults such as chronic cortisol induced CMS pathology provoking glutamatergic disinhibition on pyramidal cells provokes the synthesis of allopregnanolone
https://pubmed.ncbi.nlm.nih.gov/23227932/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578010/ and it can be demonstrated that chronic intermittent allopregnanolone provokes the functional defecits observed in CMS by inducing a tolerance to allopregnanolone through provoking microglial synaptic pruning through TPSO activation and this and other
mediating factors provoke the endocytosis of gaba a receptors, provokes the reduction in somatostatin release from sst interneuron reducing their functions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031054/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245370/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766825/ It could be demonstrated that some drugs in the SSRI class provoke allopregnanolone synthesis and SSRI induced sexual dysfunction may be a functional consequence of exacerbation of CMS pathology through allopregnanolone tolerance and endocytosis of GABA a receptors provoking glutamatergic disinhibition. Chronic stimulation of gaba a receptors by allopregnanolone provokes the synthesis and release of Neuropeptide FF which acts as a functional endogenous antagonist of mu opioid receptors blocking the activation of mu opioid receptors by endorphins which also contributes to this pathology. Administration of a neuropeptide ff antagonist
reverses opioid tolerance. https://pubmed.ncbi.nlm.nih.gov/16407169/

>>14610689
From the paper: Tolerance to allopregnanolone with focus on the GABA-Areceptor
>Changes during acute and chronic stress Allopregnanolone and THDOC are released during stress as stress activates the hypothalamuspituitary-adrenal axis that releases corticosteroids, including THDOC and allopregnanolone (Purdy et al., 1991; Serra et al., 2000; Reddy, 2003). Metabolites of glucocorticoids have also been shown to enhance the GABA-A receptor effect of allopregnanolone (Stromberg et al., 2005). The
neurosteroid allopregnanolone has previously been shown to interfere with noradrenergic and corticosteroid-mediated regulation of corticotrophin-releasing hormone release and gene transcription (Patchev et al., 1996). Those observations indicate that allopregnanolone might affect the neuroendocrine response to acute stress by influencing the hypothalamus-pituitary-adrenal axis (Patchev et al., 1996; 1997;). A repetitive stress condition in animals has been shown to result in alterations in function and sensitivity of the GABA-A receptor (Deutsch et al., 1994; Serra et al., 2000 Dong et al, 2001; Guidotti et al., 2001; Biggio et al., 2007), pointing to the possibility that chronic stress condition is related to the development of tolerance against GABA-A receptor active compounds from the adrenal glands
Rreatment with allopregnanolone is a measure to determine allopregnanolone tolerance. I do not interpret it to be a treatment of cms, Its tantamount to the administration of benzodiazepines for the mitigation of general anxiety disorder.Its demonstrated in the gaba deafferentation hypothesis that increased inflammation in the periphery increases gabaergic tone and this provokes allopregnanolone synthesis in the liver hyperammonemia and hyperbilrubinenemia provoking the activity of Heme oxygenase which provokes
the breakdown of heme into carbon monoxide, and iron and this provokes the accumulation of iron within microglial cells.
https://pubmed.ncbi.nlm.nih.gov/33212416/

>>14610689
>>14610692
Heme oxygenase-1 (HO-1) is an inducible enzyme known for its antiinflammatory, antioxidant and
europrotective effects. However, increased expression of HO-1 during aging and age-related neurodegenerative diseases have been associated to neurotoxic ferric iron deposits.
I believe the best course of action for mitigating the pathology of hepatic and diabetic enchephalopathy and gabaergic deafferentation is the administration of agents that mitigate the endocytosis of gaba receptors such as BDZ antagonists, such as the endogenous gaba a antagonist pregnenolone. It's demonstrated that
reduced insulin transport and dysfunction in insulin sensitivity in our hypothalamus leads to defects in neuronal steroidogenesis of pregnenolone and that allows for the accumulation of cholesterol into lipid rafts and a further exacerbation of neuroinflammation as pregnenolone serves important functions in mitigation of neuroinflammation and introducing pregnenolone to the brain mitigates and reverses the synaptic defecits and astrocytic swelling from hyperammonemia https://pubmed.ncbi.nlm.nih.gov/35108514/
Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and cognition.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835883/

>>14610689
>>14610692
>>14610696
This study demonstrates that neuroinflammation contributes to an increase in gabaergic tone as a defect in neuronal insulin sensitivity, glutamatergic homeostasis from reduced activity of glutamate transporter leads to glutamatergic disinhibition and chronic hyperammonemia induced activation of pyramidal cells provoking release of allopregnanolone. Its this disinhibition of gabaergic signaling within the periphery and within the brain that contributes to somatostatin dysfunction and transcriptional drift leading to a disinhibition in endozapine synthesis as gaba interferes with the functional activity of somatostatin interneurons by promoting the hyperpolarization of gabaergic interneurons leading to an exacerbation in glutamatergic disinhibition
ttps://pubmed.ncbi.nlm.nih.gov/16033417/ https://pubmed.ncbi.nlm.nih.gov/16033415/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180997/ This is known as the gabaergic deafferentation hypothesis of brain aging and it interfaces with the hypothalamic inflammation model of metabolic disorder and cognitive decline due to functional defects in insulin transport to the brain, pregnenolone steroidogenesis, processing of cholesterol and the accumulation of sphingolipids, defects in cerebral glucocereboxidase activity, ferritin turnover within the brain and this leads to functional iron deficiency leading to defects in proteostasis.
https://pubmed.ncbi.nlm.nih.gov/8717636/
https://pubmed.ncbi.nlm.nih.gov/9527011/
https://pubmed.ncbi.nlm.nih.gov/8159265/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465775/
https://onlinelibrary.wiley.com/doi/full/10.1002/jha2.321 Its demonstrated that insulin provokes the exocytosis of gaba, nmda, and ampa receptors to their cell surface and this is due to an increase in neuronal atp genesis from glucose stimulated energy metabolism and this accelerates the transport of mitochondria to synaptic vesicles.

>>14610698
>>14610689
>>14610692
>>14610696
This is supported by the first study I shared supporting the evidence that endolysosomal deacidification from opioid receptor stimulation provokes iron accumulation in the cytosol and is responsible for the opioid induced synaptic defects and neurotransmission and quite possibly reduction in neurogenesis as well. Deferoxamine completel reverses these defects observed with morphine administration It's demonstrated that ICV deferoxamine is protective against subarachnoid hemorrhage as well as intranasal deferoxamine and heme oxygenase may be partially why deferoxamine is neuroprotective. https://pubmed.ncbi.nlm.nih.gov/27618864/ It's shown that heme oxygenase activators potentiate the analgesia from opioids and provoke the exocytosis of opioid receptors to the cell surface. https://pubmed.ncbi.nlm.nih.gov/25204546/ https://pubmed.ncbi.nlm.nih.gov/23358127/ https://pubmed.ncbi.nlm.nih.gov/26730587/
Intranasal deferoxamine has 200 fold higher brain exposure that peripheral administration and has significantly lower systemic exposure while eliminating the neccesity of lengthy multiple hour long intravenous injections. https://pubmed.ncbi.nlm.nih.gov/19509317/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911954/
https://sma.org/abstracts/intranasal-deferoxamine/
https://smaorg-bucket.s3.amazonaws.com/video/PIT/2021_PIT/Abstracts/Session6A_B/Kosyakovsky.mp4

Within the united states Insulin is available OTC and it's most affordable at Our Trusted Supplier. I use 100IU or more of intranasal insulin daily for cognitive enhancement and the mitigation of neurological and metabolic disorders. Intranasal insulin has been demonstrated in controlled human trials in healthy subjects as well as diabetics for improving resting state brain connectivity, synchronicity, gabaergic functions, glutamatergic homeostasis as well as improving markers of oxidative stress, NMDA/gaba/ampa receptor phosphorylation and surface expression. Intranasal insulin is shown to be safe and without inducing changes in peripheral glucose metabolism that may be associated with hypoglycemia. Intranasal insulin improves peripheral insulin sensitivity by improving the cellular functions of cells within the hypothalamus and olfactory bulb that are responsible for glucose sensing and metabolic homeostasis. Increasing insulin transport to the brain from intranasal use reduces hepatic lipid accumulation, reduces hepatic glucose production, and reduces pancreatic insulin and peptide C release demonstrating improvements in peripheral insulin sensitivity. It's demonstrated in neurological disorders aggravated by LPS and type 2 diabetes as well as disorders such as Depression, anxiety disorders, and neurodegenerative diseases like dementia there's a reduced transport of insulin from the periphery into the brain and this leads to a dysfunction in neurotrophin supply to the brain. Neuronal insulin resistance leads to breakdown in neuroendocrine functions such as hypothalamic steroidogenesis of pregnenolone and this aggravates neurological dysfunction. LPS is the causal link tying both neurological dysfunction and metabolic syndrome and it's been demonstrated in mice intranasal insulin reverses metabolic syndrome as well as prevents or mitigates the progression of neurodegenerative diseases.

>>14610711
The following studies will have citations listed in order.
https://pubmed.ncbi.nlm.nih.gov/25249577/
>This proof-of-concept, randomized, double-blind, placebo-controlled study evaluated the effects of a single 40 IU dose of insulin or saline in 14 diabetic and 14 control subjects. Resting-state functional connectivity between the hippocampal region and default mode network (DMN) was quantified using functional MRI (fMRI) at 3Tesla. Following insulin administration, diabetic patients demonstrated increased resting-state connectivity between the hippocampal regions and the medial frontal cortex (MFC) as compared with placebo (cluster size: right, P = 0.03) and other DMN regions. On placebo, the diabetes group had lower connectivity between the hippocampal region and the MFC as compared with control subjects (cluster size: right, P = 0.02), but on insulin, MFC connectivity was similar to control subjects
https://www.sciencedirect.com/science/article/abs/pii/S0006899319305281
https://academic.oup.com/biomedgerontology/article/71/1/30/2614162
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502723/
>The excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2), mostly located on astrocytes, are the main mediators for glutamate clearance in humans. Malfunctions of these transporters may lead to excessive glutamate accumulation and subsequent excitotoxicity to neurons, which has been implicated in many kinds of neurodegenerative disorders including Alzheimer’s disease (AD) Our results showed that expressions of insulin receptor, phospho-insulin receptor, phospho-protein kinase B, phospho-mammalian target of rapamycin, and EAAT1 and EAAT2 were decreased by the Aβ1–42 oligomers in a dose-dependent manner (p < 0.05) and this trend could be recovered by insulin treatment (p < 0.05)
https://pubmed.ncbi.nlm.nih.gov/25711529/

>>14610711
>>14610715
It's demonstrated in ICV streptozotocin models in mice Alzheimers can be rapidly induced which shows a direct connection to amyloid beta induced insulin resistance within the brain aggravated by iron dysbiosis from LPS stimulation.
These effects can be replicated in mouse models where LPS is the smoking gun of cognitive decline in dementia and it's shown that Alzheimers does not occur in mice with TLR4 knockout.
https://www.frontiersin.org/articles/10.3389/fnins.2020.602508/full
https://www.sciencedirect.com/science/article/pii/S0969996120300474
https://pubmed.ncbi.nlm.nih.gov/11248117/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612444/
https://www.nature.com/articles/41792
>Here we report that insulin causes the type A γ-aminobutyric acid (GABAA) receptor, the principal receptor that mediates synaptic inhibition in the CNS8, to translocate rapidly from the intracellular compartment to the plasma membrane in transfected HEK 293 cells, and that this relocation requires the β2 subunit of the GABAA receptor. In CNS neurons, insulin increases the expression of GABAA receptors on the postsynaptic and dendritic membranes. We found that insulin increases the number of functional postsynaptic GABAA receptors, thereby increasing the amplitude of the GABAA-receptormediated miniature inhibitory postsynaptic currents (mIPSCs) without altering their time course. These results provide evidence for a rapid recruitment of functional receptors to the postsynaptic plasma membrane, suggesting a fundamental mechanism for the generation of synaptic plasticity
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2004.02841.x
These effects are replicated in mouse models of intracerebral pancreatic islet transplantation. The effects of insulin on gaba receptor surface expression and inhibition are directly in opposition to amyloid beta

>>14609632
>don't feel a thing
Yeah I'm sure his legs can't feel a thing with the state of that spine

>>14610711
>>14610715
>>14610717
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957181/
https://pubmed.ncbi.nlm.nih.gov/30175977/
>Owing to the reduced tendency of its molecules to form hexamers, the rapid-acting insulin analog insulin aspart (ASP-I) is more rapidly absorbed than RH-I after subcutaneous administration. Since after intranasal insulin administration, ASP-I may also be expected to access the brain, we examined whether intranasal ASP-I has stronger beneficial effects on declarative memory than RH-I in humans. Acute (40IU) and longterm (4 × 40IU/day over 8 weeks) effects of intranasally administered ASP-I, RH-I, and placebo on declarative memory (word lists) were assessed in 36 healthy men in a betweensubject design. Plasma insulin and glucose levels were not affected. After 8 weeks of treatment, however, word list recall was improved compared to placebo in both the ASP-I (p<0.01) and the RH-I groups (p<0.05). ASP-I-treated subjects performed even better than those of the RH-I-treated group (p<0.05). Our results indicate that insulin-induced memory improvement can be enhanced by using ASP-I
https://pubmed.ncbi.nlm.nih.gov/29508509/
>A total of 38 studies in 1092 individuals receiving acute human intranasal insulin treatment and 18 studies in 832 individuals receiving human intranasal insulin treatment lasting between 21 days and 9.7 years were identified. No cases of symptomatic hypoglycaemia or severe adverse events (AEs) were reported
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471380/
https://pubmed.ncbi.nlm.nih.gov/19458242/
In mice made prediabetic via diet-induced obesity, IND was no longer effective in increasing long-term object memory recognition nor increasing anxiolytic behavior, suggesting state dependency or a degree of insulin resistance related to these behaviors
This study explains the mechanisms through kv1.3channel blockade

Genetics play an exceptionally large factor in intelligence and cognition. I believe epigenetic factors are much greater contributors to cognitive functions and cognitive decline. There's determinants such as maternal inflammation, folate, and iron deficiencies, drug use in pregnancy, chronic stress/diet all exert strong effects on gene transcription and mechanistic data supports the evidence that these factors have in changing cognition
Much of what I understand and research is based on the application of research from observing epigenetic modulation with insulin sensitivity and iron dysbiosis.
There's so many other genetic factors, neuropeptides, and small molecules that can target these disorders and improve cognitive function
I believe that there's substantially more evidence to support the targeting of aging and cognitive dysfunction at a wholistic level through the understanding of hypothalamic inflammation, cerebral insulin resistance, and iron dysbiosis being applied to improve cognition and most metabolic disorders. This is what the evidence in mouse models of metabolic syndrome supports as well as genetic models of extreme longevity such as ames dwarf mice which demonstrate significantly stronger glutamatergic homeostasis and reduced inflammation compared to wildtype mice. These mice dont have a decline in cognitive or metabolic functions with aging, live 70% longer than wild type mice and are significantly smarter than wild type mice and this is based on them being genetic dwarfs with defective growth hormone receptors but significantly stronger insulin sensitivity and insulin transport past the blood brain barrier supporting significantly improved metabolic homeostasis and neuronal synchronicity.

>>14610727
There's also mechanistic data supporting gabaergic dysfunction with the accumulation of gaba within the body due to liver dysfunction promotes Gaba deafferentation with defects in homeostatic control of peripheral gabaergic tone and increasing bilirubin/ammonia promote cognitive dysfunction by building up in hyperammonemia.
https://pubmed.ncbi.nlm.nih.gov/25711529/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349719/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104773/
This relationship is also supported by transgenic overexpression of growth hormone in mice promotes significantly faster cognitive aging with 5 month old transgenic gh overexpression mice having the cognitive function of 25 month old wild type mice
https://academic.oup.com/endo/article/146/2/920/2878783
https://journals.sagepub.com/doi/abs/10.1177/15353702-0322807-05
https://www.sciencedirect.com/science/article/abs/pii/S0031938401004231
>Results for the old normal animals agreed with the current literature, in that the ability of old animals to retain learned information declined over time. However, retention in the old GH-R-KO mice did not decline between the 24-h, 7-day and 28-day retention tests and did not differ from young animals.
It's demonstrated mechanistically that insulin improves glutamatergic homeostasis by improving the activity of glutamate transporters from astrocytes as well as stimulating glucose metabolism in our brain cell lines. Insulin also evokes strong functions on processing of cholesterol within the brain and neuronal insulin resistance leads to the decline of hypothalamic pregnenolone production and this leads to defects in lipid rafts, transcriptional drift with a disinhibition of allopregnanolone release(endozapines) from chronic activation of glutamate from glutamatergic disinhibition and this provokes excitotoxicity and endozapine mediated microglial pruning of synapses through tspo.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769071/

>>14610727
>>14610728
https://pubmed.ncbi.nlm.nih.gov/23506423/
Inflammation increases the expression of genes that promote iron accumulation within our braincell lines and this directly contributes to cerebral insulin resistance and protein misfolding disorders.
nature
.com/
articles/s41598
-021
-88840-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593079/
Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
it's demonstrated in mouse models of ICV streptozotocin injections in mice that intranasal Deferoxamine is protective for cognitive functions and restores insulin receptor expression and phosphorylation within the brains of these mice
https://www.sciencedirect.com/science/article/abs/pii/S0022510X17304628
>Accumulation of metal and the accompanying increase in oxidative stress and inflammation plays an important role in neurodegenerative disease. Deferoxamine (DFO) is a metal chelator found to be beneficial in several animal models of neurodegenerative disease and insult including Alzheimer's disease, Parkinson's disease, stroke, and subarachnoid hemorrhage. In this study, we determine whether intranasally (IN) administered DFO is beneficial in the intracerebroventricular streptozotocin (ICV STZ) rat model of sporadic Alzheimer's disease, which is different from previous models in that it exhibits dysregulation of insulin metabolism as well as oxidative stress and inflammation.
>Spatial memory tests with the Morris water maze showed that STZ rats treated with IN DFO both before and after model induction had significantly shorter escape latencies. Pre-treatment with IN DFO also significantly decreased footslips on the tapered balance beam test. Brain tissue analyses showed DFO treatment decreased oxidation as measured by oxyblot and increased insulin receptor expression. These results further support the potential of IN DFO for use as a treatment for Alzheimer's disease, and show benefit in a non-amyloid/tau rodent model.

>>14610727
>>14610728
>>14610732
So here I'm demonstrating a mechanistic relationship between iron dysbiosis and insulin resistance within the brain and that's supported in both animal models of induced insulin resistance, iron overload, and mechanistic data of transgenic models of mice that have superior insulin receptor sensitivity as a result of growth hormone receptor knockouts
https://pubmed.ncbi.nlm.nih.gov/35108514/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835883/
These observations in mouse models and in humans with Hepatic and diabetic encephalopath with mechanistic data supporting insulin resistance as the causal factor in neurodegenerative diseases and metabolic disorders sharing a central mechanism inducing the dysfunction of somatostatin inhibitory interneurons and declines in gabaergic inhibition as a result of loss of neurogenic supply, ATP production as a result of mitochondrial dysfunction and the degeneration of brain cells as a consequence of neuronal insulin resistance recapitulates the defects shown in late stage diabetes and the expression of neurological disorders.
https://www.biorxiv.org/content/10.1101/2021.03.30.437706v1.full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766825/
This confirms the gabaergic deafferentation hypothesis as a result of diabetic and hepatic encephalopathy, reduced insulin sensitivity in the brain, and iron accumulation within the brain leading to gabaergic dysfunction, loss of proteostasis and iron accumulation in the brain promoting cognitive decline and all metabolic disorders. https://pubmed.ncbi.nlm.nih.gov/8717636/
https://pubmed.ncbi.nlm.nih.gov/9527011/
https://pubmed.ncbi.nlm.nih.gov/8159265/

I have also used intranasal creatine monohydrate which is shown to be efficiently taken up into the brain by intranasal administration and mitigates cognitive dysfunction in models of creatine transporter deficiency.
https://pubmed.ncbi.nlm.nih.gov/34324436/
>We found that CrT-deficient (CrT-/y) mice harbored dendritic spine and synaptic dysgenesis. Nurtured newborn CrT-/y mice maintained baseline brain ATP levels, with a trend toward signaling imbalance between the p-AMPK/autophagy and mTOR pathways. Starvation elevated the signaling imbalance and reduced brain ATP levels in P3 CrT-/y mice. Similarly, CrT-/y neurons and P10 CrT-/y mice showed an imbalance between autophagy and mTOR signaling pathways and greater susceptibility to cerebral hypoxia-ischemia and ischemic insults. Notably, intranasal administration of Cr after cerebral ischemia increased the brain Cr/N-acetylaspartate ratio, partially averted the signaling imbalance, and reduced infarct size more potently than intraperitoneal Cr injection.
It's observed in cases where the creatine transporter is blocked in brain slices it's seen that brain slices cultured with Creatine gluconate under creatine transporter block show superior survival and energy metabolism than control brain slices
https://pubmed.ncbi.nlm.nih.gov/26930002/
>In this paper, we investigated three creatine salts, creatine ascorbate, creatine gluconate and creatine glucose. --- Finally, creatine gluconate was superior to creatine in increasing tissue content of creatine after transporter block and slowed down PS disappearance during anoxia, an effect that creatine did not have. These findings suggest that coupling creatine to molecules having a specific transporter may be a useful strategy in creatine transporter deficiency.
I pinch a little creatine monohydrate in my fingers and snort it
Creatine gluconate is shown to raise the phosphocreatine content in brain slices 4 fold over controls.

BTW Im choosing not to talk with that Picard anon atm. He has obligations to meet with me and the community at large. I feel that this coupled with his behavior towards me as well as participating in the mass impersonation campaign and threatening to alert authorities about me is enough reason for me to stop interacting with him until he chooses to correct these issues. Octreotide is $6k deep and the peptide hasn't started synthesis from the second lab afaik. This is after the first lab we worked with made octreotide linear instead of cyclic and then they did synth studies with reagents that wasted time for months since the peptide wasn't even made properly.

>>14610770
He's asked me since then "Do we bind X to the N-terminus" and I told him I'm supporting you financially so you can figure that out. I've given him several thousand to cover his living expenses, buy HA-P6, and help cover D21.

>>14610770
>>14610782
This is all awhile he's been neurotic and mentally abusive towards me for the past year

>>14610770
>>14610782
>>14610784
stating things such as I'll never understand how to increase IQ

>>14610770
>>14610782
>>14610784
>>14610785
and factors that improve health can't improve iq with blocktexts of IQ IQ IQ for whole paragraphs.

>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
I've asked him to stop each time that he'd gotten upset and maintained my composure with him every time that it happened.

>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
I told him that if he continued to act in this way I'd show everyone the kind of person that he is.

>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
At this time he's a neurotic, egotistical, narcissist who only has concern for himself

>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
and is irresponsible with the resources and goodwill that people have given him

i have started to hear "voices" within white noise / background like my ac unit. what can explain this?

>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
in the end I never lost my composure and good soul and humanity

>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807

>>14610807
make a thread asking sci how they will dismiss this https://sma.org/abstracts/intranasal-deferoxamine/

>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
and he needs to personally correct these issues so that he can finish what I've been financially supporting him to finish

>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
and what the community has loaned him thousands of dollars to complete.

>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
Otherwise at this point of time he's an incompetent fraud.

>>14610818
>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
neuroscientists truly are the most retarded of scientists. They live in their IQ mindbox and can't fathom how IQ factors into g

>>14610821
>>14610818
>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
for /med/ to have a future, these people need to go

>>14610818
You are extremely autistic and appear to have a nominal understanding of what you're researching. /med/ is not your playground to whine in autistic woe about how your discord friend upset you.

Fuck off.

>>14610824
>>14610821
>>14610818
>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
you're all legitimately psychotic from all the iron accumulation. Take some deferoxamine

>>14610834
>>14610824
>>14610821
>>14610818
>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809

>>14610836
>>14610834
>>14610824
>>14610821
>>14610818
>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
the picard anon has multiple projects that is currently in works including a project I had paid him to make last may for $25k called octreotide hylauronate

>>14610841
>>14610836
>>14610834
>>14610824
>>14610821
>>14610818
>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
it was the proposal for a Blood brain barrier penetrable somatostatin analog for the treatment of neurological disorders

>>14610847
>>14610841
>>14610836
>>14610834
>>14610824
>>14610821
>>14610818
>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809

>>14610848
>>14610847
>>14610841
>>14610836
>>14610834
>>14610824
>>14610821
>>14610818
>>14610816
>>14610813
>>14610770
>>14610782
>>14610784
>>14610785
>>14610787
>>14610789
>>14610793
>>14610797
>>14610801
>>14610807
>>14610809
It would have been the first drug in its class.

I think you're the one who needs medical treatment you fucking retard

>anon comes in with schizophrenia
>give him a lethal dose of morphine

Everyone make sure to thank the jannie for cleaning up the schizo posts for free

Fellas what are your thoughts on ECT as first-line treatment for the /med/-autism subtype of schizophrenia
I think some bilateral zappies could really clear up these threads

>Finally get a gf
>She is double vaccinated + booster
>Starts coughing randomly everyday for the past month
>"It's nothing anon, I always get it during season change"
>Realize it's actually the effects of mRNA juice to her ACE II receptors.

She might be sick forever now.
>Realize it's because of the

>Finally get a gf
>She is double vaccinated + booster
>Starts coughing randomly everyday for the past month
>"It's nothing anon, I always get it during season change"
>Realize it's actually the effects of mRNA juice to her ACE II receptors.

She might be sick forever now.

>>14609074
he's right thoughever

>>14607091
If a patient were to take a prescribed dose of medication, Let's say 18mg of Methylphenidate and 40mg of Fluoxetine a day before a urine drug test without taking it months prior, would it read as normal or would it be known that the patient has only taken it recently?

>>14611430
did it happen immediately after getting vaxx?

>>14611430
you don't know what an ACE II receptor is

>>14607091
What kind of psychological issues are children of the pandemic going to grow up to have? Will they become schizos?

What's the easiest & least painful & less complicated method to "end" my existence ?
basically i want a method that is very quick & not very painful & have a near 99% chance to succeed.

keep in mind that i took this decision after long thoughts & rational thinking that made me conclude that this is the best option for me & the least painful since i've had an extremely shitty life & very bad things happening to me since i came to this world & i'm suffering both physically & emotionally, & that nothing you're gonna say is gonna change my mind,

pills are shit & very painful, i tried several times to kill myself with pills when i was young & altho i snorted an impressive amount of pills basically nothing happened apart from tachycardia & me starting to uncontrollably shaking for couple of hours, i'm extremely afraid of overdosing on pills cause your organs/stomach/heart start hearting & beating very fast & it make me feel that i'm not in control + it doesn't have a very high probability to kill you

Hanging myself? no cause it's very technical & if i fail to brake my neck it's gonna be a very slow & painful suffocation which is my biggest fear + there would be still a chance i can get rescued(not gonna happen cause nobody cares but still) & end up a vegetable or paralyzed.

jumping ? can't,not enough sufficient tall building near me & if i get rescued altho the chances are very slim, i could survive & end up paralyzed

guns ? by far the best method ever & would've been my favorite, sadly i don't have access to guns cause if i had i would've done it long time ago

ideally i would like a method which let me retain consciousness till the end & not make me "sleep", i wanna know that i'm dying & i wanna feel the moment where i would lose consciousness
once & for all


this isn't gonna violate your Hippocratic oath btw since you're actually gonna prevent unnecessary pain & suffering, & prevent someone from becoming a veggie

>>14612446
you will never be a woman

>>14609173
any generalist doctor

>>14611125
we should be using ECT first line on any schizo or person with suicidality, ECT is a tremendously effective modality that has gone out of favor purely due to political actors and because the mouth breathing animals consisting of the general public think it looks scary

>>14607091
Is there any resource for the types of cases that you can see in ED? Like neatly made flowcharts of what to do in case of chest pain, sudden headache, vertigo and other common causes of visits of ED? With symptoms, diagnostics and treatment on it? I plan to work in ED for extra money but can't find such resources and reading guidelines for every disease is time wasting and low yield. Thanks.

>>14613867
something like this

>>14611880
Did they capture your urine during the other time? Then no. Standard drug tests aren't sensitive enough to draw a lot of details out.

>>14607091
>Look in other threads
>Weird fucking complex mathematics I can't even begin to appreciate
Bros are we retarded or do they all just autistically waste time answering pointless questions?

>>14613867
Macleod's Clinical Diagnosis

>>14614742
I did a math major, most of it is midwit shit

>>14613880
Looks neat. Source?

Was just acccepted into residency for physical medicine and reabilitation. What am I in for?

>>14617442
Being an overpriced physiatrist.
T. Overpriced anesthesist

>>14607091
is my entire life a false memory

>>14617442
comfy life

Fatal ball trauma
Testicular Paralysis

>>14609173
Sitter

>>14613401
Jewelry store cleaner, do the rest of the research yourself

MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr

A couple days ago i nasal sprayed one vial of deferoxamine over the span of an hour. I dissolved it in a milliliter of bacteriostatic water so it was a lot of liquid to spray which a lot leaked out front and back of my nose but i let it absorb in skin as i didn’t want any coming out to go to waste. Basically I experienced very apparent alterations regarding internal dialogue, flow of thoughts, depth of thoughts, and generally feeling more in control. Very positive experience with how it affected mind, mood, emotions, and behavior. Later that day of using it, I felt like it was doing something physically to my brain in a way that almost can be described as minor-brief muscle spasms on random areas in my head, like synapses were having a rave of some sort, and connections were being built. Maybe this was all related to the VEGF enhancing properties. I also believe intranasal deferoxamine can intensely relieve tolerance to other drugs. Personally, one huge bonus is that intranasal deferoxamine is super friendly to the nose, promoting a constant clear airway ever since my first time using it. I had nasal problems for a few years now, with clogging, excess mucus, sleeping and waking up with blocked nasal passages, general nasal discomfort. I really hope DFO is a longterm panacea for all this, just made it super satisfying to feel fresh air penetrating smoothly into my nose/membranes. I will try DFO again next week, likely 200mg intranasal(trying my best not to let it leak from where its supposed to absorb). The DFO that got on my hands made my skin feel good and different, at the time I was wondering if it was strongly affecting my sensory pathways, enhanced senses seems very plausible with DFO intranasal. I did experience some kidney discomfort a few hours after using DFO that lasted until i woke up the next morning, and I would like to hear if anyone using intranasal dfo experiences the same thing because a study showed acute renal injury from systematic dfo.

>>14613607
Doesn't it have a risk of memory loss

>sitting in room and it's kind of cold
>start to realise my toes feel kind of funny
>pull my socks off and see that two of my toes have gone completely white
>can't feel them anymore
>panic and run warm water over them
>5 minutes later they go back to normal
Wtf?

>>14607312
>>14608107
brexpiprazole has stronger a2c adrenergic antagonism, stronger 5ht1a activation and less intrinsic activity at d2/d3 receptors. it is the most similar to clozapine. it is the best

>prazosin (a1 adrenergic antagonist) prevents memory deterioration in Alzheimer's
https://pubmed.ncbi.nlm.nih.gov/23063647/
>a1 blocker reduces risk of parkinson's
https://medicine.uiowa.edu/content/prostate-drug-associated-lower-risk-parkinsons-disease
>5ht1a agonism increases dopamine and acetylcholine in the PFC
https://www.sciencedirect.com/science/article/abs/pii/S0166432808002933?via%3Dihub
>5ht1a agonism raises striatal dopamine
https://pubmed.ncbi.nlm.nih.gov/15906386/
>cognitive benefits of a2c adrenergic antagonism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558054/

Should SSRIs really be prescribed so often? There seem to be a ton of complaints about long term sexual problems

>>14621793
congratulations, you have Raynaud's syndrome
about 1 million causes of it so happy googling (better yet see a doctor if you are concerned)

>>14621928
yes

>>14621928
yes
depressed retards should have been sterile anyway

>>14607704
you guys don't need drugs

you need binaural beats, hz frequencies, rife quantum machines

https://youtube.com/c/BioresonanceClub

>>14622625
Most based thing I've read on this board in a while

>crack neck
>feel tingles in fingers

>>14622667
thanks anon, i truly hate the whole pharmaceutical industry for keeping the sick people sick and making healthy rely more and more on pharmaceuticals, but at least they're filtering out the really bad fruits with antidepressants, antipsychotics and so on

I don't wanna diss the resident schizos, but there is an extreme correlation between low intelligence and unmanageable schizophrenia.
Now, above tangent is important for following question, as most real world data was, consequently, generally obtained from such low IQ cases.

I wonder what would happen if you took a very high IQ individual (say, 140 IQ) and gave them a lobotomy. Would their actual IQ be impacted? How much? If you are intelligent (chances are, you are, due to anthropic reasons) you know that there is the principle of "synthesizing" shit -- making up for things that are "intended" to be a lower level, semi-/sub-conscious literally amniote ("reptile") brain function to be emulated in your higher brain functions (which also geographically literally take place in a higher brain layer).
So, how much could the high IQ person use their (remaining? important difference) intelligence to make up for the modest amount of brain scrambling?

>>14623343
fuck off back to the iq general. Of course it would lower IQ, are you retarded? If the voices keep you from concentrating, you'll score lower.
Never post such low quality garbage again

I'm fucking done being a doctor.
I went through 6 years of med school even though every instinct told me this isn't any sort of life for me and I should quit. I started off my internship and within 2 weeks I wanted to kill myself every single day. Within 4 months I was hospitalized for weeks with a clostridium difficile infection that nearly killed me. They kept insisting I go to work even though I kept telling them I'm sick, so I worked until my body literally started shutting down. And then when I was lying there with sepsis they were still phoning me screaming abuse at me to come in and do my shift. I hate everything about it. I hate watching patients get screwed over again and again by fucking god complex losers. I hate how much shit gets swept under a rug and you can be an incompetent lazy fat cunt who sits in the breakroom eating KFC while the baby you were supposed to monitor dies of hypoglycemia, as long as you've worked there for a while and are somebody's friend. I hate being treated like shit and being told I'm worthless and a liability if I so much as spell a senior doctor's name wrong. I hate being forced to work subhuman hours and to be shat on because I forgot one tiny irrelevant thing after being on my feet for 28 hours. The healthcare industry breeds literal sociopaths. These people are incapable of actual empathy, they simply emulate it for their own gain like fucking dogs standing up on their back legs for a treat. Some of them are actual sadists who get off to seeing people in pain. The rest are even worse because they don't do anything out of malice, they just do it out of fucking braindead desire for money and dopamine, they'd eat their own shit on camera if they could get the same fix out of it, but instead they hurt vulnerable people.
Fuck this shit. I'm gonna get a masters in something biomedical and live a normal fucking human life. I don't even care if anyone reads my stupid blog but it sure felt good to finally say all this to someone.

Redpill me on IR

>>14623996
>being an american

>>14624240
I'm a 3rd worlder. If i wasn't done with this whole thing I'd have sucked anyone's dick just to do medicine in America because I'm pretty sure that as horrible as it is it's 10x better than how we suffer here.

>>14624240
I'm a 3rd worlder. A few months ago when I was still a gullible retard and wasn't completely blackpilled I'd have sucked anyone's dick just to do medicine in America because I'm pretty sure that as horrible as it is it's 10x better than how we suffer here.

>>14621614
yes but there are modalities that have a much lower risk of memory loss, plus you're using it on schizos, it would be easier for the vast majority of them I'm sure than being on a depot treatment order

who do skintags happen?

>>14624796
cuz u fat

if i were to really smack someone in the head with a hammer, like full force wind-up and hit them with a hammer, is that actually likely to kill them?
what exactly would happen?

>>14624950

>>14624999
i imagine it's probably pretty hard to kill someone with a hammer, and i doubt that hitting someone once, even really hard, is likely to kill someone. it might give them brain damage or something.

>>14624916
no way

>>14623400
Kill yourself, actually. My question is an extremely interesting neurology question, not an intelligence question.
You are the IQ obsessed autist, not me. You autistically hyperfocus on the presence of these letters in my post, when I was talking conceptually. I am not interested in the precise performance of the lobotomy patient in an IQ test and if that is impacted, but I was asking generally just how much one can compensate for loss of function in the damaged frontal cortex, for intelligence that (somehow?) derives from other brain regions. I thought it was clear what my aim was, but you can never account for stupid.

>my question is extremely interesting

>>14624576
>I'm a 3rd worlder.
your life would suck anyways

>>14623343
2-300

>>14625075
lol your understanding of IQ is utter garbage. Reads like what a high schooler, completely oblivious to what psychometers and neuroscientists actually work with, would write.

>>14623343
>making up for things that are "intended" to be a lower level, semi-/sub-conscious literally amniote ("reptile") brain function to be emulated in your higher brain functions
stop posting

Is Lasik eye surgery bad? How come most ophthalmologists still wear glasses?

>>14625191
Lasik long term isn't good. Attempt natural realignment before pursuing surgeries. It is not an awful substitution for natural correction though, but it is worse.

>>14625109
Yeah well maybe a little bit less.

>>14625195
>Lasik long term isn't good
how so?

>>14623996
Dangerously based anon

t. patient who got fucked over by heartless doctors

>>14625512
I'm sorry anon. I've been too. I've been misdiagnosed, given dangerous meds and in general treated like shit. That's why I did it all, I wanted to actually fucking help people unlike those self serving retards. But fuck this. I've tried and endured and it doesn't get better. The environment makes it impossible. I could straight up see myself becoming a progressively worse person and knew that at some point I wouldn't be able to look at myself in the mirror anymore. The profession is fucking doomed and I'm not going down with the ship.
If you want to help people, go into some non-useless STEM field and do literally anything else with your time.

>>14625563
Is there any way you could put your studies to use and go into medical research or something? That way couldn't you work in the same field (but different environment) whilst not having to deal with asshole docs? Plus wouldn't research be more comfy? No 28hr shifts, etc. Might be worth looking into it desu

>>14611430
Comfy sickly gf, she’s cuter that way

>>14623996
Let me guess, Poland? At least sounds exactly like it. Good thing I’m well connected so I can keep eating my KFC lmao

I'm trying to figure out of taking fish oil supplements for non alcoholic fatty liver disease is helpful or harmful. Finding mixed studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019889/ concludes it can have a positive effect. I cant seem to post any of the articles I want because of spam filters...
but then I find shit that makes me doubt it.

Sorry for messy links. I'm mobile posting. It's one of the only supplements I've seen that have actual positive non placebo effects on people with real studies but I've been doubtful on the effect of the liver for a while. Anybody have anything further to contribute? Is there just not enough research on something this specific? I feel a lot of Americans probably all are developing NAFLD so it's worth exploring.

I keep feeling like I can't breathe
Hate panic attacks

>>14625907
it's lung cancer sorry

>>14607704
Ask. If you want benzos also mention that a lot of the fear of having a panic attack is impacting your daily life, ability to function in society and is a vicious cycle. That you think not only being able to take something when a panic attack comes to remove the physical symptoms will also relieve the fear of it happening again.

If your primary care provider isn't down, go see a psychiatrist.
>>14608629
You'll be fine. Just avoid a caffeine OD and try to minimize caffeine consumption elsewhere. If you want more energy, slowly taper off caffeine use, exercise more and routinely, which will result in better, routine sleep, resulting in less daily fatigue, allowing you to live your day-to-day life without any extra.
>>14609173
Medical secretary.
>>14609181
See >>14609209

>>14611430
Seasonal allergies? Does she use air conditioning or a fan when sleeping? Have her mouth open when she sleeps?
>>14611880
Alright anons lets see if I understood my pharmacokinetics class.

Think of a drug being effectively cleared out of the body for ease of measure at 7 half lives (Ln2/kel, using first order elimination). Methylphenidate has a half life of about 3.5 hours. After about a day it'll be entirely gone from the system. Won't show up in urine next day.

Fluoxetine has a half life of greater than 24 hours in acute usage, much longer (up to a week) in chronic use. Unless they're testing for antidepressants, which they don't in standard drug tests, it won't show up, although there's a very small chance of a false positive for amphetamines or LSD, but that would be a testing error and not something to stress over. If they were testing for antidepressants, then yes it would show up the next day.

>>14625737
That's actually the plan. Looking into a masters then PhD in forensic science or toxicology. There's a lot in the medical-adjacent field but that's the shit that I actually find fun and stimulating.
>>14625775
Good guess but nah

i was prescribed testosterone and i would inject it into my quads. i ended up with a gnarly staph cyst pretty much dead-on the center of the vastus lateralis.
that was years ago, but ever since i've had this asymmetry on my quads. the one where the cyst was is somewhat recessed. i don't have any muscle weakness or whatever, my quads just don't look symmetrical. i am concerned.

Is mefloquine safe? I've heard bad things about it inducing psychosis

>>14622645
Where's the one that cures manletism

What does it mean when a doctor gives a patient a referral for a test, says they don’t expect to find anything but they think it should be done (their words) for peace of mind?
I’m a bit confused about getting this reaction because my old doctor used to go on rants about how philosophically he doesn’t think tests should be done on the rare chance that it’s something and then repeatedly asked me if it was something I wanted done while telling me he’s opposed to it which usually resulted in me saying no

>>14625801
I would assume it has to do with exercise paired with proper dietary intake. For the nonalcoholic fatty liver disease especially, exercise helps redistribute and change subcutaneous fat. Hence lifestyle interventions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864195/

The main problem with correlational dietary research is findings that associate things like "fish oil" from a higher diet in fish are capturing a self-selected population of people who are already more concerned with their health. Things like that. I could not, looking around, find a study with lifestyle intervention paired with "fish oil" specifically after one is diagnosed with the disorder, either. To be fair I did not look all that hard.
>I feel a lot of Americans probably all are developing NAFLD so it's worth exploring.
That probably has most to do with a lack of exercise, lack of walkable streets or cities, and so on. There is an increasing amount of research on that association, given people with similar diets do not have the same problems even controlling for BMI. Exercise as an independent factor seems to be huge, and inability to engage in meaningful casual exercise while doing daily tasks such as going to/from work is the biggest problem. Or that's my opinion anyway.

>>14626836
depends on the test. stuff like routine bloodwork is usually covered under insurance, so you might as well. it can alert you to illnesses when they are still very early.
same reason you get your blood pressure and pulse checked at a dr visit. you might be in for something totally unrelated, but they still check your blood pressure and pulse.

>>14626836
>What does it mean when a doctor gives a patient a referral for a test, says they don’t expect to find anything but they think it should be done (their words) for peace of mind?
They are pussies. I've been with emergency physicians who were stingy with the use of investigations and ones who would take a shotgun approach and order everything under the sun. The stingy ones tend to be better doctors who know more, are smarter and (probably, anecdotally) have better outcomes.

>>14626869
Interesting. I really thought fatty liver was purely diet, but seems that exercise makes a huge difference in it as well. So it seems that the best treatment is actually. Ore exercise if you are sedentary, followed by diet changes? If you're not sedentary then yeah you need a lot more diet changes, but essentially I guess you need to starve off the fat in your liver to treat it

im 25 and have really high BP(genetic) (150+) and i have started to have an intense fear of having a stroke rational or not. I am taking losartan + amlodopine and have started running every single day ( 20min high intensity runs) for about 2 months now should this be enough to ease my fears about having a stroke ? i refuse to test my BP bc i always freak myself out with anxiety and end up scewing a really high bp number so i refuse to do it

>>14628095
Few things from someone with similar problems
First -- relax. You're young. Yeah that's really fucking high but you're not gonna just randomly have a stroke so long as you aren't a fat fuck at your age. Generally high bp is something that compounds into your middle age. So it's good to be proactive about it now.
As far as what you can change, best thing to do is run a few times a week and then do some weight training a few times a week. There's some studies out there showing you want high intensity and low intensity to train your heart (which will help a lot). You can probably do some personal research on it. But 20 minutes of cardio a day will definitely help. Even a few times a week. Aim for something like 90 mins/week.

The best thing to do is talk to your doctor about it because if it's truly genetic then what they say will definitely be law, but ultimately its definitely something you can get under control. Keep your diet as clean as possible as well. Look at all the fat fucks our age, they definitely have high BP and you aren't seeing them die of strokes. So breathe. From a philosophical standpoint, remember that we can't change the cards that we are dealt. I'd ask your doctor about regularly testing your own BP but I was testing mine daily when I was worried about it a little more just to see how my numbers lined up but I don't know if that's useful to making better decisions. Don't do it if it stresses you out though. Controlling stress is important too.

Anyways not a doctor, just a passer by dealing with high bp as well who freaked out for a bit and these things are long battles. You're not gonna drop dead tomorrow from high blood pressure especially if you're making efforts to reduce it. Keep some baby aspirin on hand if you're ever really worried about it but yeah man just keep it up. Not a doctor and not your doctor as a reminder.

>>14628095
it'll get you out of nowhere
one day... you'll be doing groceries, visiting family, watching a movie, sleeping...
and then BAM!!!
that vessel pops open like a birthday balloon
enjoy walking around while you can

STAT CALL, STROKE ALERT, WEST TOWER SECOND FLOOR STAIRWELL

STAT CALL, STROKE ALERT, WEST TOWER SECOND FLOOR STAIRWELL

STAT CALL, STROKE ALERT, WEST TOWER SECOND FLOOR STAIRWELL

theory:

doctors are basically car mechanics but for morbidly obese, rude and obnoxiously stinky troglodytes

A few weeks ago I was having a real sharp pain on the right side of my chest whenever I inhaled deeply. The pain continued until I inhaled really fucking hard (which hurt quite a lot) and then it stopped. Today the same thing is happening however inhaling deeply didn't solve it (only tried once tho, the pain hurts). Male, young and normal BMI. What do?

>>14608182
Thats why Ibwanna be a nurse in that field and write about how fucked up and little we are from that seeningly dissaperad lobotomies.
Why carry all that racket when a few pills will castrate your brain in even worse way and condemn you to eternal constipation.
Shit is stale as fuck.

>>14623996
>I went through 6 years of med school even though every instinct told me this isn't any sort of life for me and I should quit.
I'm in my fifth year and I'm feeling like pathology or radiology is the path for me lol
>clostridium difficile infection
poo poo

>>14629343
>stroke
check medications.
slap on an oxygen mask.
book a CT
contact the on call neurology and ICU reg.
easy.

>>14607091
Does this kid looks like it's on the FAS spectrum?
>Low nasal bridge
checked
>Small eye opening
Nope
>Smooth philtrum
Checked
>Thin upper lip
Checked
>Small head
Not sure
>Flat midface
I dunno

Does this kid look like its on the FAS spectrum?
>Low nasal bridge
checked
>Small eye opening
Nope
>Smooth philtrum
Checked
>Thin upper lip
Checked
>Small head
Not sure
>Flat midface
I dunno

>>14629358
More like human maintenance technician

>>14607091
I'm a premed going into the OR for the first time tomorrow to shadow. Any advice? It's going to be a Whipple.

>go hiking three days ago
>get sunburns on face
>it's getting better now, skin is peeling off
>notice huge discoloration spots on my forehead that makes it look like I have vitiligo
Dermbros how long until this shit goes away

Is it hard to suddenly get a mental hospital admission these days?
t. 6 foot, 105 pounds male

>>14630317
yes if you had been there before for a long time and barely displayed any positive change

and no if you had been there before and have a real mental disease like schizo and you are experiencing a mental breakdown

>>14607091
what is the least stressful spec?

>>14629981
Unless you're assisting somehow you won't be seeing/understating anything

Do antihistamines lose effectiveness when someone gets sick?

>>14629981
Take some panadol before you go. You'll probably be standing on your feet for a few hours.

MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
>MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
>MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
>MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
>MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
>MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr
>MY FINAL MESSAGE TO THE /MED/ GENERAL > vocaroo.com/17xv8xPOWfXr

>>14629981
based surgeon memeing this premed into standing in the background for 9 hours while he talks shit with the residents

SNORT IVERMECTIN
>SNORT IVERMECTIN
SNORT IVERMECTIN
>SNORT IVERMECTIN
https://www.sciencedirect.com/science/article/pii/S0022354921000320
nasal ivermectin passes into the brain and targets the brain directly
where it'd exert effects on mitigating p2x4 purine receptor activation reducing inflammation in the brain and also increases the activity of Nachar 7 receptors
it checks out
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939657/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593990/

DO NOT INJECT BREAST MILK FOR STEMCELLS.
>DO NOT INJECT BREAST MILK FOR STEMCELLS.
DO NOT INJECT BREAST MILK FOR STEMCELLS.
>DO NOT INJECT BREAST MILK FOR STEMCELLS.
Go to a stemcell clinic and pay the few grand to get the procedure done. Deferoxamine can improve the pluripotency, and migration of stemcells and this is demonstrated to restore stem cell regenerative properties in stemcells from diabetic subjects and there may be evidence to support subcutaneous use of deferoxamine to improve inflammation in adipose tissue. injection of deferoxamine into wound's will improve tissue regeneration and that includes healing of bone fractures as well as non healing wounds.
> Deferoxamine preconditioning to restore impaired HIF-1α-mediated angiogenic mechanisms in adipose-derived stem cells from STZ-induced type 1 diabetic rats
https://pubmed.ncbi.nlm.nih.gov/26332145/
> Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1α
https://pubmed.ncbi.nlm.nih.gov/23726275/
> Impaired Neovascularization in Aging
https://pubmed.ncbi.nlm.nih.gov/31993253/

in my pursuit of cognitive enhancement I've learned to understand there's really only the limit of mitochondrial functions within our brain that's the main limiting factor to control of metabolic homeostasis and cognition. I have no idea where the limit is even though I've pushed so far. It's actually surreal at this point having such a strong photographic memory and I know there's a place further beyond this. I am a strong proponent of the simulation hypothesis for this reason.

>>14630479
Couldn’t you just take 2 tubes of horse paste ivermectin and it would do the same thing? In high enough dosages it crosses the blood brain barrier, no snorting required

Anyone know how these interact with ivermectin? I'm currently going through the /x/ NAC+Ivermectin protocol to kill of the fungus and have to take these meds

POST YOUR STACK
FOR ME, ITS
Morning

0.3ml Cerebrolysin IN + 333mcg Lithium orotate (3x weekly)
10mg J147 intranasal (2-3x a week)
1 pump androgel
Kisspeptin nasal spray (once every 3 days)
Melanotan-2 (once weekly maintenance)
25mg intranasal Epobis
Tadalafil (on kisspeptin days)
Bromantane (3x weekly on gym days)
100mcg Nor-BNI intranasal (weekly)
Bit of Sarcosine
25mg NR sublingual
80mg intranasal Vorinostat
2g intranasal Deferoxamine
10mg Kanna buccal
10mg Carnosine nasal spray
Microscoop agmatine
2mg Pregnenolone intranasal
10-13mg DHEA topical
1 drop BPAP sublingual
2 caps Organic gelatinized black maca
Biogaia osfortis every other day
250mg Primavie shilajit
1 tab Kyolic
1 cap WWB
1 cap Doctors best R-ALA w/ NA-R-ALA
~5G Creatine monohydrate + 50mg gluconate intranasal
100mg CoQ10
10mg PQQ
1g Royal jelly
Nicotine salts vaped, no inhalation
80IU intranasal insulin

Occasional
Amisulpride intranasal
Celebrex
10-20mg PPAP intranasal
5-10mg 4-fmph intranasal
100mcg SKQ1 intranasal
500mcg rubidium chloride intranasal
Aniracetam intranasal + piracetam
Cinnamaldehyde
Phenylpiracetam
Fisetin
1.25mg Deprenyl buccal
Rapamycin
Baclofen
Tianeptine
Lyrica

Night

1 cap Liposomal glutathione (cycled)
10mg Pregnenolone oral
N-Acetyl-Tryptophan
1.5mg intranasal brexpiprazole
250mg Carnosine every other day
3G Glycine
300mcg melatonin
2 spray NASA
Agomelatine + Pinealon 2-3x a week
Ornothine hydrochloride

i got the heckin 'rona, doc
what do i DO

>>14630569
No interactions known

>>14630620
for me, it's-
>300mg luvox the sigma-1 agonist
>100mg atomoxetine (when i have it)
>4mg brexpiprazole
>nicotine gum (when i've stolen it)
>weed (when I have it)
>shiraz red wine (I always support my local booze shop)

Cognitive Liberty! man!

>>14607091
why doctors are so arrogant? they deserve to be beaten up

>>14607091
>Feeling sick after trip to the tropics
>Nurse asks for antigen, say negative
>Nurse writes down positive anyway
>Clear up that antigen went out negative
>Doctor completely ignores the fact that I've being going to the beach on the tropics and that I didn't spend time with known infected people
>Completely ignores my gf doesn't have symptomps
>'just take paracetamol every 8hs and retake the test'
>completely ignores half the stuff I said to her
Fuck you scammers for being so retarded and letting stuff like this happen. My mom almost died last year from strep because 4 doctors refused to make a strep infection test and insisted she should take another cov test four times in a row. Fuck you scammers for making me go through this now. You're no better than fucking homeopathic or accupunture practicioners, you're fake even though you based your 'science' on the shoulders of giants you choose to walk the easy road. Your title means nothing because your use of the scientific method became 'hey just see how it evolves, globoberg wouldn't want us to run tests on other stuff when the boogie- I mean cv is still a thing'.

went to see a psychologist today and educated him on iron disbiosys its effects on aging and my experience with deferoxamine. Suffice to say, my encyclopedic knowledge of iron and its effects on cognition surprised him. This proved to me once again that modern medicine is dead and doctors are useless. Simply by reading pubmed articles for 7 years I have gathered more knowledge on cognitive decline than any psychiatrist ever has.

I have taken 500mg DFO intranasally over two days. The first few hours I felt a sense of intuitive
I first noticed time dilation, which I've always taken as a good sign from various nootropics as it's related to information processing and memory. As a reference for cognition, my digit span was previously locked at 12 digits and after DFO it increased to 15-16.
As others I've also noticed clearing of nasal passageways.
After DFO I became nigh immune to the side effects from moderate alcohol intake.
My social capability has also become more fluid and my emotions have become self-regulated again, needing no conscious or subconscious input to maintain them.
Music sounds better in a way it never did, long boring pieces of classical music suddenly became gently emotive. Any obsessive and compulsive behaviors are gone now.
I can choose to work as long as I want without running out of mental energy, only limited by my own psychology and the way I choose to orient myself which has also become easier to manipulate.
My mental state had been built upon my perseverance through my issues, and was propped up by my conscious effort. DFO removed the need for this scaffolding.
My ‘spirit’ feels lighter, and my mind has an unburdened fluidity of its own again. My spatial memory has become exceptional, I remember every street I drive through now. My thought patterns have returned to their more pleasant abstract states, music has a beauty that makes me spirit dance with joy.
As a child I had undiagnosed OCD, which eventually I overcame by exposure therapy. But the structure still layed dormant and I found myself thinking in an OCD-like way every now and then. DFO has removed it completely.
From benzo abuse, likely through kindling I gained restless leg syndrome which has also been cleansed by DFO.

>>14631414
psychologists aren't doctors thoughever, unless you meant you saw a psychiatrist

The human body naturally seeks to sequester nutrients when subjected to pathogenic attack.

This is because these nutrients in the extracellular fluid and blood are ripe for use by pathogens to increase their energy output and thus their reproduction.

The signals for this sequestration include inflammatory cytokines such as IL-1, IL-6, and TNF-α.

Iron is particularly important for pathogen replication and energy homeostasis. As such, these cytokines will increase the release of hepcidin, which then causes a shift in iron transport with a bias towards intracellular transport (via downregualtion of FPN1 and upregulation of DMT1 https://onlinelibrary.wiley.com/doi/10.1111/jnc.12244).).

But, in many chronic disease states, these inflammatory markers are released excessively and in the absence of exogenous pathogens. This then increases ROS inside of cells due to the intrinsic oxidative stress of Fe2+, which produces a positive feedback loop that only increases cytokine release, increasing hepcidin, and furthering iron sequestration in cells.

Because of their low turnover rate, this is especially problematic for organ, glandular, and nervous tissues. Unlike short-lived cell lines, they only continue to compound in dysfunction because they cannot be replaced. Of all these tissues, the nervous system has the lowest turnover rate of all.

And, as well, because neurons are involved in very complex informational relationships, and highly energy-consumptive, they are more prone to malfunction as a result of this stress than other bodily systems. This is similar in principle to how the number of moving parts in a machine decreases the resilience of the machine.
Deferoxamine is a very fortuitous compound for treating this neurological dysfunction. For one thing, it does concentrate very well in the brain when administered intranasally, with manifold concentrations compared to IV DFO.

But more than that, it also has other neuroprotective effects that are separate from simple relief of iron accumulation.

It interacts with prolyl hydroxylase enzymes to increase the expression of HIF-1α and REDD1. This basically allows it to act both as a very strong hypoxia mimetic, which can increase autophagy by inhibiting mTOR, and increase VEGF expression. HIF-1α also increases vascular permeability as well as mediating other cellular benefits seen in hypoxia https://www.nature.com/articles/cdd200812

Given the fact that my etiology seems derived from SIBO, which produces leaky gut and thus overexposure to cytokines and LPS, odds are my brain has been accumulating iron for awhile.

And there is something to be said for taking larger doses, too.

Deferoxamine has relatively low cellular permeability (https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/1097-0142(20011215)92:12<3093::AID-CNCR10107>3.0.CO;2-B).. This means that lower doses will likely asymptotic in the reduction of cell penetration and defeat the purpose of the therapy.

So yes, I'm intending to go through 500mg within the brief window that reconstituted DFO stays good--the window of 2 days.

My only reservations are due to the reports of nausea and stomach upset from DFO, but this is for IV use, and Pax has experienced none of that. Still, it will be very interesting to see.

I may also try taking it orally in a time-release capsule and seeing whether it would be of benefit to my microbiome. There is evidence of relieving oxidative stress in the microbiome producing improved outcomes. https://www.mdpi.com/2076-3921/10/10/1563/pdf

Fuck, I hate psychiatrists. I was in a mental institution/psychiatric ward for two year, put there wrongly by idiots who thought I was suicidal, depressed, had halucinations (which I didn't have and wasn't) until they figured out there was nothing wrong with me.

Just stop with the bullshit assumption I am in an asylum, it's wrong.
My family is fine but a bit controlling. I honestly can't do anything without my parents' permission, even today though they let me do whatever I want and buy whatever I want so long they have the bill.

For example, one time, I bought a daki of my waifu and my parents wondered why I was buying a 160$ pillow after they received the bill on my credit card but never said anything about it. Then when the delivery got lost, my mom personally called people in China she knew and got HobbyHeart to get them to mail me a new one free of charge and I got it within the week. That was pretty sweet.

I'm told not to go outside and drink since, like my mother said ''I don't want you to bring back a whore and get her pregnant'' so I just drink at home. I'm not really allowed to do anything though I can still do whatever I want. It's hard to explain.

When I was sent to the mental ward, my mom thought it was the best thing for me since the doctors said so, so she never really bothered with finding out how I was doing.

>>14631630
I was stuck a full fucking two years in there. Full of actual insane people.
Weird fucking faggots too, a lot of people who really just wanted to kill themselves, weirdos who kept screaming and shit, one guy who was gay and couldn't stop talking about his fucking dick, one girl who was raped by her dad and kept talking about how we would all die and it would be better if we let her kill us (all while she kept telling suicidal people how to kill themselves with their shoe laces or stab themselves with plastic knives and shit).

I can barely remember the damn two years I was there.
The drug they gave me just made me zone out and I couldn't think much of anything.

After I got out, my parents didn't give a fucking shit.
My imouto was insanely happy to see me again so it made me feel better but I just wanted to be left alone.

After that, I said I wanted my own apartment and started university.
My parents paid for everything and I was happy. Got into a funny relationship with a dumb as fuck girl who just stayed with me for a year because her parents told her to marry me. After dumping her ass, I came back home, finished Uni, got a good job with the RCMP and have been working there for awhile.

Three years ago, the family held a family conference and they wanted to know how I was doing and they got pissed at how they weren't informed that I might be insane and even more when they found out I had wasted two years doing nothing only to be found normal.

So that's why they want me deported

>>14630620
15ml intranasal breast milk mixed with 3g deferoxamine
300IU intranasal insulin
450IU intranasal EPO
200mg intranasal rapamycin
15mg intranasal methamphetamine
3ml intranasal cerebrolysin
50mg intranasal ISRIB-A17
80mg intranasal PPAP

Hey so I was making tortillas the other day and when I bit into one a bit of hot steam went onto my cheek
It hurt for about 20 minutes and now there's a red mark on my cheek
What can I do to prevent this from scarring?
I really don't want a visible scar on my face from having bitten into a tortilla

I have a septic system. Once a month I have to throw down some chlorine tablets in a tray. Did that today but didn't have gloves like I normally do because my sibling came by my hosue and literally took every single pair of gloves I own.

So I used my hands to handle the tablets (mostly just the tips of my fingers) and quickly tossed them in, saw a little bit of white powder on my finger tips and jogged over to a nearby spicket and rinsed my hands off for a few minutes, came inside and washed my hands for a few more minutes with bar soap and water

Few hours later, fingers seem fine but one feels kind of tingly if I fixate on it. But it could just be psychosomatic. How stupid am I for doing this?

This is the data sheet. It says get immediate medical attention for skin exposure but how can that be right?

https://septicfit.com/wp-content/uploads/2018/12/ECR-AST-Safety-Data-Sheet.pdf

https://septicfit.com/wp-content/uploads/2017/08/pdfresizer.com-pdf-resize-32.pdf

>>14631414
Excellently done. Now take your meds

>>14632158
Assess the 'mark'
if it's just red erythema, no problemo
if it's wound/scar/granular tissue, u fucked
that'll be 50 dollars

>>14632158
>imagine being permanently scarred by ethnic food
Diagnosis: Mental retardation

>>14633039
Yeah it could be an erythema, it just looks like pink skin
Thanks for the reassurance anon
>>14633112
Yeah I know, I'm a fucking moron :(

>>14620128
I couldn't even find it where i live,kek, plus from what i've read, while suicide by cyanide is very quick and effective, it's a very painful way to go and i will literally have every single thing i've listed in my previous post happening to me (tachycardia, difficulty breathing vomiting etc).

I'm gonna opt for the goodold cutting the wrist artery "down the road", either today or tomorrow max, definitely very soon, for some reason i started cleaning my stuff and throwing away things, as it's gonna matter to me later lmao.

The good thing about this method is that it's not very painful after it's cut and gonna feel as if i was taking a shower because my blood gonna be hot, the downside is that it's not very effective and difficult to achieve and as soon as i start bleeding alot at first i'm gonna feel cold then lose consciousness, which is the opposite of what i want, wanted to stay conscious till the end, guess you can’t eat your cake and have it too.

sadly people who attempted suicide here and fail either go to prison or psychiatric ward, so let's hope i succeed.
Don't even know why i responded and told you all of this, guess i'm just trying to cope.
Not gonna reply anymore and waste anyone's time and annoy them, i'm sorry

>>14633159
you are telling people because that's usually a sort of last attempt at reaching out for help, it's very common behavior in suicidal people. I recommend you tell at least someone close to you before you do it instead of anons on a basket weaving forum

/med/bros, how many weeks has he left?
>>14630284
>>14630284
>>14630284

>>14633667
>Liver disease mechanistically is a disorder of iron overload due to hepatic insulin resistance and that promotes the failure of proteostasis inducing iron accumulation.
Wtf is he right? Could liver disease be prevented by simply lowering iron intake?

>>14634028
no, he's schizophrenic

>>14634028
>iron
>iron
>iron
>iron
>iron
desu listening to schizos gets tiring at some point. They always latch onto one thing and try to explain everything with it.

>>14633159
you here mate ?

>>14634028
every time I hear this guy speak I want to blow my brains out. He's a factory worker that reads through pubmed articles in his free time and seems to understand nothing, yet shits up this board with misinformation and somehow even got a few retards to snort random substances.

Why do I get increased anxiety when my ADHD meds wear off? Is there some kind of interaction in the brain between the two conditions?

>>14629501
Do it, it's the only way to save your soul. Or dermatology, they work like 4 hours a day. Too bad I would have to get through 3 years total of working in utter shit conditions before I could even think of speccing.
>poo poo
Bro I straight up shat my pants multiple times with pure mucus while on duty and they still made me work 24h shifts.
>>14629981
Watching surgeries is the dumbest shit ever, you won't see or understand jack shit since you won't be allowed near the table and will just stand in the corner like a cuck. If you want to shadow go shadow in someone's consulting rooms.

>>14622865
>filtering out the really bad fruits with antidepressants
wait my doc just put me on Fluoxetine for minor depression, what am I in for? am I going to need to flush this shit down a toilet or something

>>14634976
>going to need to flush this shit down a toilet or something
NO!
That is what is causing the buildup of SSRI/NSRIs and other pharma drugs in the water supplies, which in turn is raising schitzo/depression/low-testosterone rates across the "developed" world.

Burn that shit and fire your shitty big pharma Great Reset pimp doctor.

>>14634976
fluvoxamine is the best SSRI
but fluoxetine is more activating, still a good drug, brexpiprazole and atomoxetine are the best adjuncts
>antiparkinson effects of fluvoxamine
https://pubmed.ncbi.nlm.nih.gov/32273939/
https://pubmed.ncbi.nlm.nih.gov/27338206/
>anti Alzheimer's effects of fluvoxamine
https://www.neurologylive.com/view/sigma1-agonists-offer-combination-approach-to-dementia-symptoms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819237/
>general cognition enhancing effects of fluvoxamine
https://pubmed.ncbi.nlm.nih.gov/20373470/
>sigma-1 agonists raise acetylcholine in the frontal lobes and hippocampus but not the striatum and reverse memory impairment from muscarinic blockade
https://pubmed.ncbi.nlm.nih.gov/20060423/
>fluvoxamine dopamine in the frontal lobes
https://pubmed.ncbi.nlm.nih.gov/21487652/
>prazosin (a1 adrenergic antagonist) prevents memory deterioration in Alzheimer's
https://pubmed.ncbi.nlm.nih.gov/23063647/
>a1 blocker reduces risk of parkinson's
https://medicine.uiowa.edu/content/prostate-drug-associated-lower-risk-parkinsons-disease
>5ht1a agonism increases dopamine and acetylcholine in the PFC
https://www.sciencedirect.com/science/article/abs/pii/S0166432808002933?via%3Dihub
>5ht1a agonism raises striatal dopamine
https://pubmed.ncbi.nlm.nih.gov/15906386/
>cognitive benefits of a2c adrenergic antagonism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558054/
>procognitive effects of atomoxetine
https://pubmed.ncbi.nlm.nih.gov/16231039/

>>14634983
>>14634989
>one anon says to burn the pills
>the other posts a completely unnecessary amount of studies and research on why I should take it
I feel like I just stepped into a minefield. All I wanted to know was why that other anon called antidepressants a filter

>>14608287
>>14608295
pathetic
imagine your spine being destroyed by a lightweight peanut

>>14625907
It could be a drug overdose. Is there a knee on your neck?

>>14630620
I got bad news dog, if your kidneys aren't fucked now they will be soon. Polypharmacy is one hell of a drug. Find a geriatrician to do some de-prescribing before it's too late.

>>14634889
>Too bad I would have to get through 3 years total of working in utter shit conditions before I could even think of speccing.
We all have to. When you're 80 what do you think you'll regret more? Not sucking it up those 3 years so you could spend the next 40 years of your life working a well paying, highly respected, comfy rads or path job, or dropping out to spend the next 40 years of your life not getting paid well working for Mr Shekelstein?

Most jobs suck. Most jobs out there are either public facing or office jobs. Do your three years in the trenches so you can spend the next 40 years out of them; for all you know bailing out now means spending the next 40 years in trenches instead of the next 3.

/biz/ here. I'm curious, what's your institution's current alert level on monkeypox? Do you have oral and/or IV TPOXX (tecovirimat) available? Have staff received any smallpox or monkeypox vaccines?

Thanks for your time and buy SIGA if you want, I guess.

>>14634976
>doc
>put me on
do you consent to mind altering substances just like that, because someone "put you on them"?
you're mainly for feeling like a dumb, disconnected human being with no libido nor care in the world
the studies are nice tho :^)

>>14607091
Congratulations to neurosurgeons for proving to be the most based type of doctors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062939/

>>14635292
Just don't be an homosexual

>>14635600
As long as they don't have an effect on my cognition, I don't really give a fuck. I consented to medication because, like any other, I was told it would help. I also managed to get a script of Vyvanse out of her too, so maybe I can just lean on that instead of the zombie happy pills. What the fuck do SSRIs actually do that gets everyone so damn worried?

What else should I check on bloodwork aside from labs for diabeetus and cortisol if I experience constant hunger? TSH and T4 is normal, T3 was low last time I had it tested

>>14635714
Well that's good advice regardless.

It just seems to me (based on like an hour of research) like a rapidly spreading pandemic STD that's benign for adults but absolutely wrecks pregnant women and kids when it spreads to them via aerosols or non-sexual close contact.

>>14636187
>but absolutely wrecks pregnant women and kids when it spreads to them via aerosols or non-sexual close contact.
This is a meme, media is trying to scare you.

Starting my family med rotation

Give me some apus to get me in the right mood

Where my radbros at?

Swallow the ultrasound pill to achieve CHIM
Swallow the CT pill for gains
Swallow the MRI pill for enlightenment
Swallow the flouroscopy pill for trad wife
Swallow the interventionist pill for godhood

Say no to the retarded primary care retards and their constant wallowing about DVT this DVT that when they dont know what wells score is
Say yes to ortho and boners
Say yes to clinicians and chest xrays
Say fuck you to patients who want prescriptions and sick leave

ayy lmao

Caught the China flu 9 days ago is it reasonable to see my grandmother tonight? Haven't had any symptomes the last 6 days.

>in biotech. will perform viability tests on follicular units.

where the fuck can I find biopsy punches thinner than 1.0 mm?
I need both .6 and .8 mm probably.
Could hypodermic needles work instead? Will need to do a slight twisting motion for follicle extraction.

>>14636735
I don't know if 0.6 or 0.8 exist but I've definitely seen 0.75 before

>>14607091
Why are UK residencies not recognised in the US? Are you telling me that a successful UK consultant will have to start their career from the beginning and do another residency program if they want to practice in the US?

>>14613401
Please do not kill yourself. Please call a suicide prevention hotline, either by phone or online.

>>14636868
Don't listen to this woman and kys.

I assume that her alikes are mainly the reason why you want to kill yourself. >Angry incel wants to take his life.
Better than taking others'
>p-projec
Lol

>didn't pass practice board exams
>have to delay starting rotations for a month to study
>just had a meeting where a group of school administrators took turns calling me a retard for 30 minutes
fun times bros...

>>14613867
PGY3 equivalent in GB
WikEM is great
or pay for some cheap uptodate account. lexicomp really useful

test

>>14636803
cheers, will look for it

>>14625775
kek

I just had testosterone bloodwork done, and I'm confused by the results. My total and free T levels are toward the high end of the normal range, but my SHBG is higher than it should be: 56 nmol/L (normal range: 10-50).

It's my understanding that high SHBG is a problem because it can lower free T. But clearly even with high SHBG, I still have an abundance of free T.

The reason I had the test done is because I have no libido anymore, I can barely get a boner and I can't keep it up to save my life, and my energy levels aren't good. So I was expecting to have low free T.

Is it possible the high SHBG is still causing me sex-drive and erection problems despite having plenty of free testosterone?

>>14635029
If you are so defective you can't cope with life then you shouldn't reproduce is all
Funny thing most emo fags on meds like you are anti-natalist already anyway
nothing personal btw I am just generalizing

Why would myopia stop progressing after you are subject to a lasik procedure?

>>14636861
Everyone has to, they don't recognize other countries medical degrees, unless you have connections and a local sponsor to get a fellowship position, that's the only way to practice in the US. I kind of get it, If I got into hundrets of thousands of dollars of debt to get a medical degree, I'd be seething at the prospects of foreigners just strutting in without going through a round of humiliation themselves.

I dislocated my right foot toe pretty fucking badly (about 70° left from your normal position, thought it got ripped off, was in pure horror and shock and can't get the image out of my head), but in pure shock and with some animalistic reflexes I grabbed my toe and ripped it into the other direction back to normal position. I could move it normally again, even though it hurt a little bit. The next day it was completely swollen and it hurt pretty bad, but I could still move it and now on day 2 I had few "clicks and feeling a lot better.

Basically, should I go to doctor or just wait it out? My only fear is I didn't put it back into the "optimal" position. I can move it and it feels normal, but I'm not doctor to know that. Any suggestions and what to be carefull with, other than "go to doctor"?

>>14608198
>There is no mention of mental illness before ~1920
you can't just lie on 4chan, retard.

>>14612475
>What kind of psychological issues are children of the pandemic going to grow up to have?
definitely issues related to understanding facial expressions because they weren't learned from birth. I'm guessing that'll turn into some SERIOUS autism later on in life.

>>14638977
...Yes, because a pandemic and quarantines have never happened with children before. We totally have never seen anything like this in all history, especially recent enough history to study the effects. This tooooootally is exactly what will happen.

i love nephro

>>14639999
soulless spec

>>14629515
you missed the two most important steps
i hate ER fags and how incompetent they are when it comes to neuro

>>14640364
>contact the on call neurology and ICU reg.
That's your job retard.

>>14607091
how to cure schizophrenia? my therapist Thomas is helping. He is very kind to me, but i was wonder if there is more i help myself with

>>14613401
Im trans, btw.

Hey /med/ about 4-5 months ago I was having sharp stabbing pains on the left side of my chest when I breathed in deeply. Went in to the doctor, turns out I had a collapsed lung on the left side. I got the surgery and had it reinflated, but recently I relapsed. I dont have the money or insurance for the surgery again, and I dont think Covid likes my lungs very much.

Is there any way out of this? Or will I just have to do the surgery again and go into debt? Cant leave it untreated or itll strain my heart.

>>14634028
Anemia causes liver disease. He's retarded.

>>14640984
you never needed the surgery to begin with, doc lied to you because he wanted ur money. same thing will happen 2nd time, stupid paypig

>>14640382
>it's your job to determine if it's actually stroke or a UTI in an elderly patient causing delirium
no, that's YOUR job ER cuck
go take a history, do an exam and a proper admission
then call me again

i remember once this ER ass hole called me with
>patient has trouble swallowing, you must come see them it's a stroke
patient had tonsillitis

but the classic one is
>uggh doc idk what's wrong with the patient ergo it must be neurological, i'm gonna need you to take over

>>14640359
what's a soulful spec then

What's the deal with immediate pain in the medial forefoot when flexing the hallux at the proximal joint while extending all other proximal joints of the other digits? Will this void my warranty?

Can you actually undo scoliosis through exercise/lifting or does it only stop it from getting worse?

>>14641410
family medicine
neurology
abdominal surgery
infectious disease
pathology

that's SOVL

>>14642259
>family med
today... I will make a referral
>neurology
today... I will diagnose a problem I cannot solve
>abd surg
today... I will perform appendectomy for the 200000th time
>infectious disease
maybe right
>pathology
today... I will use the microscope... the entire day

>>14642259
>pathology
literal bugmen spec

>>14609173
Sperm bank ejaculation assistant

>>14610918
This one’s legitimate, though

>>14613401
Hanging is the way to go. Just test your equipment first (several times if necessary) to make sure you get enough drop and nothing breaks. Prisoners and small children can do it. So can you if you’re not just making excuses.

>>14626619
Unfortunately this means you’re gay. There’s no cure, but I’m going to write you a prescription for 100 cocks in your mouth and ass every day. I know it will be difficult for you, but please try not to exceed 100.

>>14641410
CHADNESTHESIA

>>14642391
>infectious disease
today... I will treat the STI of this homosexual

>>14643677
Can povidone-iodine aka Betadine be used to protect against nuclear attack?

Can povidone-iodine aka Betadine be used to protect against nuclear attack?

DEFEROXAMINE CURES CANCER

> High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines
https://pubmed.ncbi.nlm.nih.gov/29562821/
> An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells

> Fryknäs, M., Zhang, X., Bremberg, U. et al. Iron chelators target both proliferating and quiescent cancer cells. Sci Rep 6, 38343 (2016).
https://doi.org/10.1038/srep38343
> Deferoxamine Inhibition of Human Neuroblastoma Viability and Proliferation
https://aacrjournals.org/cancerres/article/48/24_Part_1/7189/493542/Deferoxamine-Inhibition-of-Human-Neuroblastoma
> Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death
https://www.frontiersin.org/articles/10.3389/fonc.2021.794735/full
> Deferoxamine Increases Breast Cancer Radiosensitivity

> Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
https://www.e-cep.org/journal/view.php?number=2009520212
> A Case of Positive Tumor Marker Response after Intra-arterial Deferoxamine Infusion Therapy in a Hepatocellular Carcinoma Patient with Decompensated Liver Function
https://www.e-jlc.org/journal/view.php?doi=10.17998/jlc.14.2.127

Intranasal deferoxamine targets the brain primarily and suppresses inflammation improving central insulin sensitivity and this has downstream effects within the periphery by improving insulin sensitivity, insulin transport to the brain as well as supporting the function of our hypothalamus.
> Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

>>14641410
Rural GP with interest in obstetrics

>>14609317
There is some evidence to indicate that the stress response triggered in the body by anxiety can cause cases of covid to be more severe

>>14622812
Hemorrhagic stroke inbound

>antiparkinson effects of fluvoxamine
https://pubmed.ncbi.nlm.nih.gov/32273939/
https://pubmed.ncbi.nlm.nih.gov/27338206/
>anti Alzheimer's effects of fluvoxamine
https://www.neurologylive.com/view/sigma1-agonists-offer-combination-approach-to-dementia-symptoms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819237/
>general cognition enhancing effects of fluvoxamine
https://pubmed.ncbi.nlm.nih.gov/20373470/
>sigma-1 agonists raise acetylcholine in the frontal lobes and hippocampus but not the striatum and reverse memory impairment from muscarinic blockade
https://pubmed.ncbi.nlm.nih.gov/20060423/
>fluvoxamine dopamine in the frontal lobes
https://pubmed.ncbi.nlm.nih.gov/21487652/
>prazosin (a1 adrenergic antagonist) prevents memory deterioration in Alzheimer's
https://pubmed.ncbi.nlm.nih.gov/23063647/
>a1 blocker reduces risk of parkinson's
https://medicine.uiowa.edu/content/prostate-drug-associated-lower-risk-parkinsons-disease
>5ht1a agonism increases dopamine and acetylcholine in the PFC
https://www.sciencedirect.com/science/article/abs/pii/S0166432808002933?via%3Dihub
>5ht1a agonism raises striatal dopamine
https://pubmed.ncbi.nlm.nih.gov/15906386/
>cognitive benefits of a2c adrenergic antagonism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558054/
>procognitive effects of atomoxetine
https://pubmed.ncbi.nlm.nih.gov/16231039/

>>14643904
see >>14643895

Is it true 50% of doctors during the residency abuse drugs they're not supposed to have?

>>14643904
I've been telling you guys this for a while: THE KEY TO STOPPING AGING IS SNORTING SALMON SPERM EXTRACT.
Iron chelation with deferoxamine from the cytosol of neurons increases adenosine A2A receptor surface expression, which increases cellular trafficking of TKRB receptors to the cell surface.
Salmon sperm PDRN is an A2A receptor agonist that is shown to act on neural stem cell niches to promote neurogenesis. WE CAN MIX PDRN AND DEFEROXAMINE AND POTENTIATE BOTH!

REQUIRED READING FOR /MED/:
>REQUIRED READING FOR /MED/:
https://encyclopedia.pub/item/revision/f1d14114ad78c12f72f1226086278c8f
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784599/
https://pubmed.ncbi.nlm.nih.gov/20573894/
https://pubmed.ncbi.nlm.nih.gov/19860658/
This is the FINAL PIECE to understanding the reversal of BDNF resistance within neurons and neural progenitor cells.

>>14643954
There was a time when I first found PDRN (The salmon coom extract) and I started recommending it to people... but they injected it
we can probably look at Placentex next intranasally. Don't you want to impregnate your neural progenitor cells? The DFO studies on stem cell viability are some of the best data I've seen in the literature: It completely restores pluripotency and migration of stem cells in streptozotocin-diabetic mice. That means we can go to a stem cell clinic, get adipose stem cells extracted, and culture the stem cells with DFO.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178011
https://www.tandfonline.com/doi/abs/10.1517/14712598.2013.782390

DOES /MED/ KNOW ABOUT NEUROMELANIN? THEY DONT WANT YOU TO KNOW ABOUT IT

Neuromelanin is fucked up. It's like a ticking time bomb that soaks up toxic substances and elements. Eventually it's overfilled and when it does spill over it explodes and that's only the start as it causes a cluster explosion of surrounding neuromelanin containing neurons. We need ways to simultaneously reduce the metabolites and iron availability. Maclura tricuspidata polyphenols are good ways to do both, maybe helped by other biflavanoids to improve chelation. However, MAO B inhibition may be an issue if VMAT2 function isn't on point with the conformational status and expression / density as autoxidation generates even more toxic metabolites and more oxidative load. So this discovery that Bipolar patients have increased risk of PD is very troubling, as it implies the transporter is working in the opposite direction creating great oxidative load in a very short period of time the person is manic.

>>14643979
In a perfect world we need to (by order of importance/predicted effectiveness):

1. Stabilize VMAT2 conformation to open-to-in (how?)
2. Increase VMAT2 density (via GDNF upregulation and DJ-1 protection by PQQ, or better yet DJ-1 upregulation but there isn't a known way to do this still)
- note: GDNF upregulation preventative ability is questionable as TH upregulation causes oxidative stress, while VMAT2 upregulation decreases it. The effect of both over time may cancel out, while it provides remarkable recovery from already present PD because of increased DA availability.
3. Find a potent antioxidant that chemically prevents autoxidation and enters the dopaminergic neuron through DAT (while also stabilizing it to an open-to-in conformation if possible)
4. Chelate cytosolic iron and copper with non-toxic means (biflavanoids and isoflavones, respectively). Question is whether these substances even enter dopaminergic neurons and how do they get out, if they simply accumulate in the cytosol it's no bueno.
5. Stop formation of some of the toxic metabolites by partially inhibiting MAO B (Maclura isoflavones)
5. Increase the antioxidant pathway of DA autoxidation metabolites by improving glutathione synthesis.

https://www.sciencedirect.com/science/article/abs/pii/0024320587902979
https://onlinelibrary.wiley.com/doi/10.1111/jnc.15432

>>14643979
I was thinking about snorting aerosolized puerarin due to the water solubility and bad oral bioavailability. This is mediated by the G protein coupled estrogen receptor. https://pubmed.ncbi.nlm.nih.gov/23512787/
https://www.researchgate.net/publication/309561854_GPR30_Activation_Contributes_to_the_Puerarin-Mediated_Neuroprotection_in_MPP-Induced_SH-SY5Y_Cell_Death

Phytoestrogens are based AF.

help. my dad got a stroke 8 years ago and is turning 60 this year. he's alright now other than a limp on his left leg. is it still possible for him to regain full movement at this point? i want to encourage him to exercise more. i don't want him to have bad quality of life later on.

unfortunately for him he didn't get to go to the doctor right away when it happened, otherwise he would've gotten away scot free.

>>14643075
>today... I will beat my previously high score in candy crush

>>14643513
lol

I tore my pec two years ago. Yesterday I played rugby and i now had minor bruising near where the tendon attaches to the humerus. Did I partially re tear it or is just broken up scar tissue? I have full ROM and can do push-ups just fine.

how can we purge advice seekers and schizos from our threads

>>14644377
You can start by taking your meds.

>>14643724
Answer me Medfuckers

>>14644399
I should indeed take paracetamol for the headache these posts are causing me

>>14624576
>being a pajeet

How many hours can I realistically work at a part time job during med school? And getting decent grades of course.

>>14644536
don't do it anon. You won't make it out alive

>>14643075
utterly and completely soulless robot work unless you also are an intensivist, then it's a cool combo

>>14644683
How did you guys support yourselves during med school then?
I'm thinking of doing bar work just on the weekends. My undergrad was in Chemistry so semester 1 of Medicine doesn't look too hard considering my background

>>14642167
Help me med bros I don't want to work out for nothing

let's say I'm an opera nerd and wanted to help opera singers maintain their voices etc.
Is that mainly a speech pathologist job or could I specialise in something like ENT or resp with an MD?

why would anyone become a doctor in europe

>>14636861
yes fuck off bong

>>14648087
same but for JAV and boobs/asses

>>14647020
I took out a loan and was a stingy bitch. I’m glad I did because a week in the hospital could be soul-crushing, sometimes you need time to study and prepare rounds/patients/presentations so you’ll barely have time off anyway. Personally I couldn’t have imagined working next to it. But boomers will call me a lazy zoomer so idk

So I've done all my ankis for all the systems (though I barely remember anything). Now have this consolidation semester where we do symptom-based and revision. Best resources for algorithms based on presenting complaint?

so what's really going on with addiction?
i take amphetamine every day, and have done for years, as prescribed. i don't really feel much in the way of compulsion to do it. if i miss a day or two, i don't feel an urge to take some, i just feel more sleepy and i remember "ah yeah i didn't take any speed today".

but, at the start of covid, i started vaping. i dunno why, i have never smoked a cigarette before. but, there is a different "compulsion" feeling with nicotine. almost like i am "encouraged" to do it by something in my brain. like i understand how addiction works and all, but i also don't notice any subjective effects from the nicotine.

when i take amphetamine, within an hour or so i definitely notice the change in consciousness. i feel more motivated, there's a clear "okay i've taken something" feeling. like what happens when you notice that you're drunk. same sort of thing.
but with nicotine, i don't notice anything at all. hitting a vape doesn't result in any tangible change in my experience, yet, it makes the "hey you should go vape" encouragement-feeling go away for a bit.
akin to scratching an itch. i want to learn more about this but i don't really know what i'm trying to describe.

how to get into psychiatry? what degree sets one up best for med school with a goal of being a psychiatrist

>>14649380
also,
are there any volunteering opportunities for getting first hand experience

>>14607710
What is a doctor shopper? Not that guy also not into substances but i've never heard of this. It sounds expensive.

>>14609181
I am 2x pfizer a year ago, had coof pretty bad recently. No remaining issues I'm aware of, I was doing regular cardio and my performance is 100% back.>>14609209

>>14647020
>How did you guys support yourselves during med school then?
Most people either take out loans or have rich parents paying for everything.
>I'm thinking of doing bar work just on the weekends
Don't.
>My undergrad was in Chemistry so semester 1 of Medicine doesn't look too hard considering my background
Get through anatomy first, then see if you feel the same way.

>>14636468
Based and radpilled

Am i going to die?

>>14651072
Eventually, yes.

>>14651072
get the fuck out of this thread

>>14613499
definitely not this

>>14609173
either psych or occupational health
anaesthetics is also a bit of a doss if you're working in theatre

>>14651093
Dont you mean PISS off?

>>14651453
kek
Carlos!

fuck endocrinology and fuck Cushing retards

I'm terrified of colon cancer

>>14652378
then spread those cheeks and let me check boy

>>14652424
Okie bby

But how the fuck are you supposed to know that you have it until it's ready spread and grown? I'm worried about any small tummy pain or anything that looks red or somewhat dark when I take the kids to the pool. Shits fucked

Not seeking advice, but if my shrink never gave me a diagnosis does that mean that there's nothing wrong with me? I never asked him about a diagnosis, though.

How common is it for doctors to be on stimulants?

>>14652981
probably as common as anyone else to be on them.

>>14653006
No. More common because they have free access to them

has anyone here had experience with testicular torsions? I have a slight achey-ish pain in my right testicle and I really don't want it to be a torsion

>>14652857
ask for your record
>>14653222
torsions aren't ''slight achey-ish''
>>14652639
you'll lose weight, feel like shit, lose appetite, unexplainable fever, etc. Most countries offer to determine CEA levels in your shit as a preventive measure, you can ask for that

Great day at the office. That'll be 50$ each.

>>14643786
it's a very interesting compound and it'd be highly beneficial to us if you were to share your human trials' data as opposed to only ever claiming that people had great experiences with it.

>>14653222
torsions don't do that, but there are many types of deadly cancer that can

I generally have nutrition down, but other than keeping omega ratios I'm too ADD for fats and vegans as well as farming lobbies make it hard to believe the shitty studies they churn out. What is the prefect lipid profile to consume?

How often do you diagnose people with schizoid personality disorder?

whats your diagnosis?
>title of pic related